ANCIENT WISDOM
ANCIENT WISDOM
MODERN SCIENCE
MODERN SCIENCE

ANCIENT WISDOM

LION'S MANE

(Hericium erinaceus)

Lion’s Mane is a striking mushroom native to Asia, North America, and Europe. Its unique properties are due to two families of compounds that it produces - the erinacines and hericenones, which have great potential. Studies have shown they may help stimulate the generation of Nerve Growth Factor (NGF). Celebrated for centuries for its wide-ranging health it has recently gained attention in clinical research for its potential neuroregenerative properties.

Lion's mane contains various beta-glucans and other cell wall polymers.

LEGEND & FOLKLORE

Lion's Mane is a saprophytic mushroom celebrated for its rich history in traditional medicine and culinary uses – it’s perhaps little wonder to have significance to East Asian Zen Buddhist and Shaolin monks as well as scholars. This revered functional mushroom has been treasured for thousands of years.

Its numerous benefits have been explored and continually validated through generations of study and use. Its unique appearance and restorative properties earned it a reputation as a symbol of wisdom and vitality, aligning with its nickname as a "mushroom for the mind". Historically it has gone by many names, including "Yamabushitake" (Mountain Priest) in Japan, "Pom Pom Blanc" (White Pom Pom) in France and "Hóu Tóu Gū" (Monkey Head Mushroom) in China.

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MODERN SCIENCE

SCIENCE INFORMATION REVIEW

LION’S MANE

(Hericium erinaceus)

Welcome to the Fung Shui Lion's Mane scientific research page which connects you to our ever evolving library of research and peer-reviewed papers and articles. These articles are here to further educate us in the potential role of mushrooms in human health.

The use of Lion's Mane is currently being explored by modern scientific research. A triple extraction method—using both water and alcohol and ultrasonic—increases the beneficial compounds that are extracted, including polysaccharides, beta glucans, hericenones and erinacines.

Their bidirectional effects make them adaptogenic, meaning they help the body find balance in different systems.

Below we have collated a list of scientific articles and books relating to Lion's Mane. You can find various articles in the research references below in the 'peer reviewed papers and articles' section.

More human trials are needed to further this field of research to more fully understand its efficacy. This page is not medical advice.

PEER REVIEWED PAPERS & ARTICLES

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  1. (2018) Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines
  2. https://pmc.ncbi.nlm.nih.gov/articles/PMC1738560/
  3. Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. Journal of Natural Products, 79(9), pp.2264-2269.
  4. Vigna, L., Morelli, F., Agnelli, G.M., Napolitano, F., Ratto, D., Occhinegro, A., Di Iorio, C., Savino, E., Girometta, C., Brandalise, F. and Rossi, P. (2019). Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evidence- Based Complementary and Alternative Medicine, 2019, pp.1–12
  5. Sánchez C. Reactive oxygen species and antioxidant properties from mushrooms. Synthetic and Systems Biotechnology. 2017 Mar;2(1):13–22.
  6. Chong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. International Journal of Molecular Sciences. 2019 Dec 25;21(1):163.
  7. Hericium erinaceus - A Rich Source of Diverse Bioactive Metabolites. Fungal Biotec. 2021 Jan 1;1(2):10–38.
  8. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research [Internet]. 2009 Mar;23(3):367–72. Available from: https://pubmed.ncbi.nlm.nih.gov/18844328/
  9. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer's Disease Mouse Model
  10. https://pubmed.ncbi.nlm.nih.gov/18844328/
  11. https://www.researchgate.net/publication/335150912_Improvement_of_cognitive_functions_by_oral_intake_of_Hericium_erinaceus
  12. https://pubmed.ncbi.nlm.nih.gov/20834180/
  13. https://pubmed.ncbi.nlm.nih.gov/23557368/
  14. Mhyre T. R., Boyd J. T., Hamill R. W., Maguire-Zeiss K. A. Parkinson’s disease. Subcellular Biochemistry. 2012;65:389–455. doi: 10.1007/978-94-007-5416-4_16. [DOI] [PMC free article]
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  15. Kuo H. C., Lu C. C., Shen C. H., et al. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. Journal of Translational Medicine. 2016;14(1):p. 78. doi: 10.1186/s12967-016-0831-y.[DOI] [PMC free article]
    [PubMed] [Google Scholar] [Retracted]
  16. Wang L.Benzinger T. L., Su Y., et al. Evaluation of tau imaging in staging
    Alzheimer disease and revealing interactions between β-amyloid and tauopathy. JAMA Neurology. 2016;73(9):1070–1077. doi: 10.1001/jamaneurol.2016.2078. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Das P., Verbeeck C., Minter L., et al. Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology. Molecular Neurodegeneration. 2012;7(1):p. 39. doi: 10.1186/1750-1326-7-39. [DOI] [PMC free article]
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  18. DeMattos R. B., Lu J., Tang Y., et al. A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer’s disease mice. Neuron. 2012;76(5):908–920. doi: 10.1016/j.neuron.2012.10.029. [DOI] [PubMed] [Google Scholar]
  19. Tsai-Teng T., Chin-Chu C., Li-Ya L., et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. Journal of Biomedical Science. 2016;23(1):p. 49. doi: 10.1186/s12929-016-0266-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Strober L. B., Arnett P. A. Assessment of depression in three medically ill, elderly populations: Alzheimer’s disease, Parkinson’s disease, and stroke. The Clinical Neuropsychologist. 2009;23(2):205–230. doi:
    10.1080/13854040802003299. [DOI] [PubMed] [Google Scholar]
  21. Chen Y.-W., Lin P. Y., Tu K. Y., Cheng Y. S., Wu C. K.Tseng P. T. Significantly lower nerve growth factor levels in patients with
    major depressive disorder than in healthy subjects: a meta-analysis and
    systematic review. Neuropsychiatric Disease and Treatment. 2015;11:925–933.
    doi: 10.2147/NDT.S81432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Chu X., Zhou Y., Hu Z., et al. 24-Hour-restraint stress induces long-term depressive-like phenotypes in mice. Scientific Reports. 2016;6(1, article 32935) doi: 10.1038/srep32935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Chiu C.-H., Chyau C. C., Chen C. C., et al. Erinacine A-enriched Hericium erinaceus
    mycelium produces antidepressant-like effects through modulating
    BDNF/PI3K/Akt/GSK-3β signaling in mice. International Journal of Molecular
    Sciences. 2018;19(2):p. 341. doi: 10.3390/ijms19020341.[DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Nerve growth factor and diabetic neuropathy. Pittenger G, Vinik A. Exp Diabesity Res. 2003;4 (4):27-85. Review.
  25. Long-term treatment with recombinant NGF for HIV-associated sensory neuropathy. Schifitto G et al. Neurology. 2001;57:1313-1316.
  26. Neuroregenerative Potential of Lion’s Mane Mushroom, Hericium erinaceus (Bull.:Fr.) Pers. (Higher Basidiomycetes), in the Treatment of Peripheral Nerve Injury (Review). Wong KH Naidu M, David RP, Bakar R, Sabaratnam V. Int J Med Mushrooms, 2012; 14(5):427-446.
  27. Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum. Saito T et al. J Antibiot (Tokyo). 1998 Nov; 51(11):983-90.
  28. Anti-MRSA compounds of Hericium erinaceus. Kawagishi H et al. In J Med Mushr. 2005
  29. In vitro anti-helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom (higher Basidiomycetes) Shang X, Tan Q, Liu R, Yu K, Li P, Zho GP. In J Med Mushrooms. 2013
  30. Frontiers in Cellular Neuroscience, 2020
  31. International Journal of Molecular Sciences, 2013
  32. Biomed Research, 2010
  33. International Journal of Molecular Sciences, 2013
  34. Frontiers in Cellular Neuroscience,
    2020
  35. Food & Function, 2018
  36. https://pubmed.ncbi.nlm.nih.gov/28266682/
  37. https://www.ars.usda.gov/research/publications/publication/?seqNo115=295111
  38. https://www.healthline.com/nutrition/lions-mane-mushroom
  39. https://pubmed.ncbi.nlm.nih.gov/23510212/
  40. https://pmc.ncbi.nlm.nih.gov/articles/PMC10675414/
  41. https://www.urncst.com/index.php/urncst/article/download/653/408/11584
  42. https://www.researchgate.net/publication/385668089_The_Cognitive-Enhancing_Effects_of_Lion's_Mane_in_A_Rodent_Model_of_Attention-Deficit_Hyperactivity_Disorder_ADHD_A_Research_Protocol

DISCLAIMER

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This website has not yet been reviewed by UK MHRA and should not replace medical care so please check with your healthcare professional. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Our tinctures are not intended to diagnose, treat, cure or prevent any diseases. Fung Shui nor nor any of its affiliated companies accept neither liability nor responsibilty to any any person with respect to loss, injury or damage caused, or alleged to be caused, directly or indirectly by the information contained in advertisments, this website or product labelling.

High Strength Lion’s Mane Mushroom Tincture Liquid Extract

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