ANCIENT WISDOM
REISHI
(Ganoderma lingzhi)
Wide ranging potential health benefits are due to its combination of highly active immune-modulating polysaccharides and over 130 triterpenoid compounds, which are researched as possibly being beneficial to support a balanced inflammatory response, histamine levels as well as being a sedative, anti-hypertensive and help with uncontrolled cell growth.
It has been used for centuries in an attempt to treat a range of health conditions such as uncontrolled cell growth, heart disease and bronchitis. Beauty sleep is important and Reishi is potentially perfect for this due to its sedative properties.
Reishi has now found its way firmly into modern wellness and biohacking culture.
LEGEND & FOLKLORE
Reishi has long been associated with the Taoist quest for immortality - revered by emporers and Sages alike. Steeped in legend, this sacred fungus has been linked to alchemy and divine realms, its mythical status far exceeding that of a mere medicinal mushroom. It is no surprise therefore that it is nicknamed 'The Mushroom of Immortality' or '10,000 year mushroom' (Mannentake).
In oriental culture it is historically (via Daoist sages) linked with good fortune, health, wisdom and happiness and even god-like powers, being the bridge between Earth and Heaven.
Japanese samurai warriors were known to consume it before battle for endurance, resilience and strength beyond mortal limits.
SCIENCE INFORMATION REVIEW
REISHI
(Ganoderma lingzhi)
Welcome to the Fung Shui Reishi scientific research page which connects you to our ever evolving library of research and peer-reviewed papers. Below we review how Reishi supports various aspects of health.
Where a reference is provided, you can find the corresponding number in the research references towards the bottom of the page in the 'peer reviewed papers and articles' section.
More human trials are needed to further this field of research to more fully understand its efficacy. This page is not medical advice.
SLEEP
Reishi mushrooms have been traditionally used to promote relaxation and improve sleep quality. Modern research indicates support for these claims, suggesting several mechanisms by which reishi may enhance sleep:
• Sedative and Hypnotic Effects: Reishi contains triterpenoid compounds that may exhibit sedative properties, potentially aiding in the initiation and maintenance of sleep. [8] A study identified 34 sedative-hypnotic components in reishi, which may contribute to the sleep-enhancing effects. [2]
• Interaction with the GABA Pathway: Reishi has been shown to have potential to interact with the GABAergic system, which plays a crucial role in promoting relaxation and sleep. By influencing this pathway, reishi may help reduce sleep latency and improve sleep quality. [4]
• Stress and Anxious Reduction: As an adaptogen, reishi may help the body manage stress, which is a common cause of sleep disturbances. By modulating the body’s stress response, reishi may promote relaxation and facilitate better sleep. [6]
• Possible Effects to support a balanced inflammatory response: Chronic inflammation can disrupt sleep. Reishi properties may help alleviate inflammation-related sleep issues, promoting more restful sleep. [6]
ALLERGIES/AUTO-IMMUNE CONDITIONS
Studies indicate that Reishi mushrooms are renowned for their potential to support immunomodulation and a balanced inflammatory response meaning it could be particularly useful for auto-immune conditions, such as psoriasis, ulcerative colitis and rheumatoid arthritis.
Bioactive compounds, particularly polysaccharides and triterpenoids, have been studied for their potential to enhance the activity of white blood cells, thereby bolstering the body’s defense mechanisms. Studies have indicated that reishi may modulate both innate and adaptive immune responses, potentially benefiting individuals with compromised immune systems. [1]
Research indicates that its strong anti-histamine activity and an ability to manage the body's overreaction to pollen or other allergens, give it unique potential benefits for sufferers of allergies such as hayfever (allergic rhinitis). [9]
UNWANTED CELL GROWTH (ONCOLOGY)
Research suggests that reishi mushrooms have a long history of use in potential oncological treatment. [10] Compounds (polysaccharides and triterpenes) within the mushroom have demonstrated the potential ability to inhibit the proliferation of unwanted cells and enhance the efficacy of conventional treatments. For instance, studies have shown that the triterpenes in reishi extracts may induce apoptosis (programmed cell death) in various unwanted cell growth lines, including breast, prostate, and colorectal.
In the case of prostate uncontrolled cells, it has been shown to block androgen receptors. [11] However, more rigorous clinical trials are needed to confirm these effects in humans. [3]
MENOPAUSE
Reishi is researched for it's potential ability to support the hypothalamic-pituitary-ovarian (HPA) axis, possibly aiding in the regulation of estrogen production. This support might enhance the sensitivity of estrogen receptors, optimizing the hormone’s efficacy even as its levels decline during menopause. Such modulation could alleviate common menopausal symptoms, including hot flashes and mood fluctuations. 
Inflammation support and antioxidant
Studies indicate that the triterpenoids and polysaccharides in Reishi exhibit potential significant support for a balanced inflammatory response and antioxidant effects. These properties may mitigate chronic inflammation and oxidative stress, both of which are linked to menopausal discomforts.
Mood and Sleep
Menopause often affects mood and sleep quality. Reishi has been researched for its adaptogenic qualities that may support the body for stress, anxiety, and depression, promoting emotional stability. Additionally, its calming effects could improve sleep patterns, addressing insomnia commonly experienced during menopause.
Immune System Support
Reishi is studied for its immunomodulatory capabilities, which may be particularly beneficial during menopause when immune function may fluctuate.
[14][15]
ANTIOXIDANT & INFLAMMATORY BALANCE
Studies indicate that the potential antioxidant properties of reishi mushrooms could help combat oxidative stress, which is linked to chronic diseases and ageing. Additionally, their possible support of a balanced inflammatory response might mitigate inflammation-related conditions. Research has demonstrated that reishi can exhibit strong antioxidant activities, scavenging free radicals and reducing lipid peroxidation. These potential effects are primarily attributed to its polysaccharides and triterpenes. [2]
BLOOD SUGAR REGULATION
Some studies indicate that reishi mushrooms might aid in blood sugar control, which is beneficial for individuals with blood sugar issues or those at risk. The polysaccharides in reishi have been researched and observed to lower blood glucose levels in animal models by enhancing insulin sensitivity and modulating glucose metabolism. However, human studies are limited, and more research is needed to confirm these effects. [2]
CARDIOVASCULAR & RESPIRATORY HEALTH
Reishi mushrooms have been studied to indicate they may contribute to heart health by supporting/correcting cholesterol levels and blood pressure. Some studies have reported possible reductions in “bad” LDL cholesterol and triglycerides, along with modest improvements in blood pressure. [5]
One randomized, double-blind, multi-centred study using a polysaccharide extract showed improvements in ECG, palpitations/shortness of breath and chest pain.[12]
Reishi has traditionally been used to treat Bronchitis, allergic asthma and altitude sickness. [13]
LIVER
The potential hepatoprotective effects of reishi mushrooms have been explored in various studies. They are said to help protect the liver from damage caused by toxicity and support its overall function. They may inhibit liver fibrosis, normalise liver enzymes and reduce inflammation. Animal studies have demonstrated that reishi extracts may reduce liver enzyme levels and histopathological changes induced by toxic agents, suggesting a protective effect. [6]
ANTIMICROBIAL - INFECTIONS
Studies indicate Reishi mushrooms may exhibit antimicrobial properties against a range of pathogens, including bacteria and viruses. This suggests potential applications in preventing or managing infections. In vitro studies have shown that reishi extracts might possess antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as antiviral effects against herpes simplex virus. Further research is warranted to fully understand the clinical relevance of these findings. [2]
MENTAL WELLBEING & FATIGUE
Some studies have explored the effects of reishi mushrooms on mental health, noting potential reductions in fatigue and improvements in well-being among certain populations. For example, a study on individuals with neurasthenia reported decreased fatigue and enhanced well-being after reishi supplementation. Another study found that patients with uncontrolled cell growth in their breast experienced reduced fatigue and improved quality of life following reishi intake. [4]
THE BIOHACKER STACK
Radically transform your life with our carefully created Biohacker Stack. Designed for those who demand more from their mind and body, this set combines nature’s most powerful adaptogens and nootropics to optimise focus, energy, performance and recovery— all in one effortless and game changing routine.
Crafted with premium, organic ingredients, each product in the Biohacker Stack is dual extracted, 1:3 ratio and fruiting body only. It works synergistically to enhance cognitive clarity, support immune resilience, and elevate your performance, whether you’re conquering the gym, bossing the boardroom, or just getting better all round.
"An incredible gift to yourself or a loved one"
Raphael Rampello - Fung Shui customer